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搶嫗擾岺戝妛丒攡郪懽巎乮堚揱巕嵶朎岺妛乯丒怉暔偺娐嫬墳摎偺尋媶乮僉乕儚乕僪丗姡憞僗僩儗僗丄墫僗僩儗僗丄懴墫惈丄傾僽僔僔儞巁丄ABA丄僔僌僫儖揱払丄儕儞巁壔丄僾儘僥僆乕儉丄儕儞巁壔僾儘僥僆乕儉丄僔僗僥儉惗暔妛乯
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怉暔儂儖儌儞傾僽僔僕儞巁偺僔僌僫儖揱払婡峔

ABA傾僽僔僕儞巁乮ABA乯偼丄怉暔儂儖儌儞偺堦偮偱1960擭戙偵敪尒偝傟傑偟偨丅ABA偼怉暔偺拞偱條乆側惗棟嶌梡傪敪婗偟傑偡乮恾1乯丅偨偲偊偽丄ABA偼庬巕偺惉弉偵廳梫側栶妱傪壥偨偟偰偍傝丄惓忢側庬巕偺宍惉偵晄壜寚偱偡丅傑偨丄怉暔偑姡憞側偳偺娐嫬僗僩儗僗傪庴偗偨嵺偵丄ABA偑媫懍偵崌惉偝傟丄怉暔偺娐嫬墳摎偺梫偲側傝傑偡丅偙偺傛偆偵丄ABA偼擾嬈惗嶻偵偲偭偰廳梫側惈幙傪僇僶乕偟偰偄傞偙偲偐傜丄偦偺嶌梡儊僇僯僘儉傪抦傞偙偲偼廳梫側尋媶壽戣偲側傝傑偡丅巹偨偪偼丄怉暔偺嵶朎撪偱婲偙偭偰偄傞斀墳乮僔僌僫儖揱払乯偵拝栚偟丄ABA偺嶌梡儊僇僯僘儉傪暘巕儗儀儖偱柧傜偐偵偡傞偙偲傪栚巜偟傑偡丅

恾1 怉暔偺惗妶娐偲ABA偺惗棟嶌梡

仧 ABA偺僔僌僫儖揱払宯偵偮偄偰 乮曇廤拞乯

怉暔偵偍偗傞ABA偺僔僌僫儖揱払宯偺奣梫偼丄2009擭偵柧傜偐偲側傝傑偟偨丅怉暔偑姡憞僗僩儗僗摍偵偝傜偝傟傞偲丄ABA偑媫懍偵崌惉偝傟丄壓偺恾偵帵偡3偮偺拞悤場巕偑夞偡傞儊僇僯僘儉偵傛偭偰偦偺僔僌僫儖偑揱払偝傟丄僗僩儗僗懴惈側偳偺昁梫側墳摎傪桿摫偟傑偡乮恾2乯丅

ABA signaling pathway

恾2丂怉暔偵偍偗傞ABA僔僌僫儖揱払偺拞悤宱楬

亂嶲峫亃
僾儗僗儕儕乕僗乮2009擭9寧22擔乯
乽楎埆娐嫬偵墳摎偡傞怉暔儂儖儌儞乽傾僽僔僕儞巁乿偺墳摎宱楬傪夝柧乿

偙偺ABA僔僌僫儖揱払宱楬偺拞偱丄巹偨偪偼摿偵SnRK2偲屇偽傟傞僞儞僷僋幙偵偮偄偰尋媶傪峴偭偰偄傑偡丅SnRK2偼僞儞僷僋幙儕儞巁壔峺慺偺堦庬偱丄懠偺僞儞僷僋幙偵儕儞巁婎傪晅壛偡傞偙偲偱僔僌僫儖傪挷愡偡傞摥偒傪帩偭偰偄傑偡丅巹偨偪偼丄偙偺SnRK2偵偮偄偰庡偵埲壓偺帠暱傪柧傜偐偵偡傞偙偲傪栚揑偲偟偰偄傑偡丅

1. SnRK2偺婎幙僞儞僷僋幙偺扵嶕

2. SnRK2偺妶惈壔儊僇僯僘儉偺夝柧

3. 恖堊揑側SnRK2偺妶惈惂屼媄弍偺奐敪


SnRK2偺婎幙僞儞僷僋幙偺扵嶕乮儕儞巁壔僾儘僥僆乕儉乯

幨恀 忋弎偺傛偆偵丄怉暔懱撪偱ABA偑崌惉偝傟偨偲偒丄偦偺忣曬偼SnRK2偵傛傞僞儞僷僋幙偺儕儞巁壔偲偄偆宍偱弌椡偝傟傑偡丅儕儞巁壔偲偼丄東栿屻廋忺偲屇偽傟傞僞儞僷僋幙偺婡擻傪挷愡偡傞偨傔偺巇慻傒偺堦偮偱丄條乆側惗暔偱僔僌僫儖揱払偵巊傢傟偰偄傑偡丅偟偐偟側偑傜丄SnRK2偑嬶懱揑偵偳偺傛偆側僞儞僷僋幙傪儕儞巁壔偟偰偄傞偺偐偼傛偔傢偐偭偰偄傑偣傫偱偟偨丅SnRK2偺儕儞巁壔偺僞乕僎僢僩乮婎幙乯傪扵偡偵偼丄怉暔偵偍偗傞儕儞巁壔僞儞僷僋幙傪偱偒傞偩偗偨偔偝傫夝愅偟側偗傟偽側傝傑偣傫丅偦偙偱丄巹偨偪偼怉暔偺儕儞巁壔僞儞僷僋幙傪戝婯柾偵夝愅偡傞偨傔偵丄乽儕儞巁壔僾儘僥僆乕儉夝愅乿偵庢傝慻傫偱偄傑偡丅

丂僾儘僥僆乕儉夝愅偲偼丄惗懱撪偺僞儞僷僋幙傪堦搙偵戝検偵夝愅偡傞偙偲傪偄偄丄儕儞巁壔僾儘僥僆乕儉夝愅偱偼偦偺懳徾傪儕儞巁壔僞儞僷僋幙偵峣偭偰偄傑偡丅巹偨偪偼丄偙偺媄弍傪梡偄偰僔儘僀僰僫僘僫偺栰惗宆偲SnRK2寚懝曄堎懱傪梡偄偰丄ABA張棟帪偵偍偗傞儕儞巁壔僞儞僷僋幙検傪斾妑偟丄曄堎懱偵偍偄偰儕儞巁壔儗儀儖偑尭彮偡傞僞儞僷僋幙傪尒弌偟傑偟偨丅偙傟傜偺僞儞僷僋幙偼丄SnRK2偺婎幙岓曗偱偁傝丄尰嵼偦傟偧傟偺僞儞僷僋幙偵偮偄偰婡擻夝愅傪恑傔偰偄傑偡丅

亂嶲峫亃
僾儗僗儕儕乕僗乮2013擭4寧10擔乯
乽怉暔儂儖儌儞乽傾僽僔僕儞巁乿偺墳摎宱楬傪戝婯柾偵夝柧乿

SnRK2偺妶惈壔儊僇僯僘儉偺夝柧

幨恀 ABA偺僔僌僫儖揱払宯偵偍偄偰SnRK2偑偦偺婡擻傪敪婗偡傞偨傔偵偼丄儕儞巁壔峺慺偲偟偰偺妶惈偑忋徃偡傞昁梫偑偁傝傑偡丅媡偵丄ABA偑側偄偲偒偼晄梫側僔僌僫儖偑峴偐側偄傛偆偵丄妶惈偑梷偊傜傟偰偄傑偡丅偟偨偑偭偰丄SnRK2偺婡擻傪棟夝偟傛偆偲巚偊偽丄偳偆偟偰傕偦偺妶惈壔儊僇僯僘儉傪柧傜偐偵偟側偗傟偽側傝傑偣傫丅巹偨偪偼丄SnRK2偺東栿屻廋忺偺夝愅傗丄憡屳嶌梡僞儞僷僋幙偺夝愅摍偐傜丄SnRK2偺妶惈壔儊僇僯僘儉偵敆傞傋偔尋媶傪懕偗偰偄傑偡丅

恖堊揑側SnRK2偺妶惈惂屼媄弍偺奐敪

SnRK2 disruptantABA偺庡側惗棟婡擻偱偁傞庬巕敪払偺惂屼傗丄姡憞傗墫僗僩儗僗懴惈偺惂屼偼丄偄偢傟傕廳梫側擾嬈宍幙偱偡丅偙傟傜偺宍幙偼丄SnRK2偺妶惈偵傛偭偰巟偊傜傟偰偄傞偲偄偊傑偡丅偟偨偑偭偰丄SnRK2偺妶惈傪帺嵼偵挷愡偡傞偙偲偑偱偒傟偽丄姳偽偮傗墫奞偵傛傞擾嬈惗嶻偺僟儊乕僕僐儞僩儘乕儖傪峴偭偨傝丄嶌暔偺庬巕昳幙偺埨掕壔傪恾傞偙偲偑偱偒傞傛偆偵側傞偐傕偟傟傑偣傫丅偦偙偱丄巹偨偪偼恖堊揑偵SnRK2偺妶惈傪惂屼偡傞偨傔偺媄弍奐敪偵庢傝慻傫偱偄傑偡丅



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